Center for Vaccine Research

Charles A. Scanga, PhD

  • Research Assistant Professor
  • Microbiology & Molecular Genetics

Dr. Scanga is a Research Assistant Professor in the Department of Microbiology and Molecular Genetics. He received his Ph.D. in Molecular Virology and Microbiology from the University of Pittsburgh in 2000. He did a Post-Doctoral Fellowship at the National Institutes of Health (Bethesda, MD) where he studied the mechanism by which intracellular parasites and bacteria, such as T. gondii and M. tuberculosis, induce HIV gene expression as well as the role of Toll-like receptors in triggering immune responses to intracellular parasites. He then worked as a Senior Scientist at the Aeras Global TB Vaccine Foundation (Rockville, MD) where he coordinated and conducted studies to evaluate the immunogenicity and protective efficacy of tuberculosis vaccine candidates using mouse, guinea pig, and non-human primate models. He joined the faculty at the University of Pittsburgh School of Medicine in 2008.

Research Interests

Dr. Scanga’s research utilizes imaging techniques such as PET/CT to follow in vivo the response of tuberculosis to antibiotic regimens in non-human primates with the ultimate goal to help design more effective chemotherapeutic regimens. He has over 30 publications, serves on the Editorial Boards of Infection and Immunity as well as Clinical and Vaccine Immunology, and is a reviewer for several other journals. Research interests include: 1) Use of novel imaging modalities such as PET/CT to monitor disease progression and response to therapy in animal models of infectious diseases, with particular interest in tuberculosis, and 2) Analysis of immune responses to M. tuberculosis and tuberculosis vaccines.