Center for Vaccine Research

Andrea Gambotto, MD

  • Associate Professor
  • Surgery

Dr. Gambotto is an Associate Professor in the Department of Surgery at the University of Pittsburgh, School of Medicine with secondary appointments in Infectious Diseases and Microbiology and the Molecular Genetics and Biochemistry. He is also the Director of the Vector Core Facility in the Molecular Medicine Institute. He received his MD in Medicine in 1994 from the University of Bari in Italy. His research interests focus on the development of vaccines and immunotherapy.

Representative Publications

  • Kim E, Erdos G, Huang S, Kenniston T, Falo LD Jr, Gambotto A.  Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation. EBioMedicine. 2016 Nov;13:315-320. doi: 10.1016/j.ebiom.2016.09.028.
  • Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, AlHajri F, Osterhaus AD, Haagmans BL, Gambotto A. Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice. Vaccine. 2014 Sep 3. pii: S0264-410X(14)01199-2. doi: 10.1016/j.vaccine.2014.08.058.
  • Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A. Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model. J Virol. 2014 May;88(9):5100-8. doi: 10.1128/JVI.03194-13.
  • Gambotto A, Barratt-Boyes SM, de Jong MD, Neumann G, Kawaoka  Y. Highly Pathogenic H5N1 Influenza Virus Infection in Humans. The Lancet. 2008 Apr 26; 371 (9622): 1464-75.
  • Gao W, Soloff A, Lu X, Montecalvo A, Nguyen DC, Matsuoka Y, Robbins PD, Swayne DE, Donis RO, Katz JM, Barratt-Boyes SM and Gambotto A. Protection in mice and poultry from lethal H5N1 avian influenza through adenovirus-based immunization. J Virol. 2006 Feb;80(4):1959-64.
  • Gao W, Soloff A, Lu X, Montecalvo A, Nguyen DC, Matsuoka Y, Robbins PD, Swayne DE, Donis RO, Katz JM, Barratt-Boyes SM and Gambotto A. Protection in mice and poultry from lethal H5N1 avian influenza through adenovirus-based immunization. J Virol. 2006 Feb;80(4):1959-64.
  • Barratt-Boyes SM, Soloff A, Gao W, Liu XG, Brown K, Rajakumar PA, Nwanegbo, Robbins PD, Murphey-Corb M, Day RD and Gambotto A. Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5-and 35-based vectors. J Gen Virology. 2006 Jan;87(Pt 1):139-49.
  • Nwanegbo E, Vardas E, Gao W, Whittle H, Sun H, Rowe DT, Robbins PD, and Gambotto A. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States. Clin Diagn Lab Immunol. 2004 Mar;11(2):351-357.
  • Gao W, Tamin A, Soloff A, D’Aiuto L, Nwangebo E, Robbins PD, Bellini W, Barratt-Boyes S, and Gambotto A. SARS vaccine: a comprehensive immunoresponse in Rhesus macaques. The Lancet.  2003 Dec; 362 (9399): 1895.
  • Gao W, Robbins PD, and Gambotto A. Nucleotide sequence of human adenovirus type 35: genome structure analysis and generation of E3-deleted recombinant virus. Gene Ther. 2003 Nov;10(23):1941-9.

 

 

Research Interests

  • MERS-CoV vaccine development
  • Zika Vaccine development
  • RSV Vaccine development
  • Highly pathogenic influenza vaccine development
  • Immunotherapy
  • Chimeric TCR genetic engineering of T cells